The Web health | how is repatha administered Repatha is administered as a subcutaneous injection, typically once every two weeks or once monthly, depending on your prescribed dose. It comes in a prefilled SureClick autoinjector or prefilled syringe for easy at-home use. In some cases, an on-body infusor may be used for higher doses. Always follow your healthcare provider’s instructions for proper injection technique, site rotation, and storage. Repatha should be used regularly to effectively manage high cholesterol levels.