What is SCEL?
SCEL stands for Sciellin, a protein encoded by the SCEL gene.
It’s a scaffold protein involved in cornified envelope formation in keratinocytes.
Plays a role in epidermal differentiation and barrier function.
Mainly expressed in skin, hair follicles, and other epithelial tissues.
? What are SCEL Antibodies?
Antibodies developed to detect sciellin protein.
Available as monoclonal or polyclonal, raised against human, mouse, or rat SCEL.
Target epitopes can be at N-terminal, C-terminal, or central domains of the protein.
? Applications of SCEL Antibodies
Immunohistochemistry (IHC)
Detect sciellin expression in epidermis, hair follicles, or pathological skin samples.
Immunofluorescence (IF)
Visualize subcellular localization (often in keratinocyte plasma membranes).
Western Blot (WB)
Confirm protein expression levels across tissues or in disease models.
ELISA
Quantify SCEL protein levels in samples.
Flow Cytometry (less common)
Analyze sciellin expression at a single-cell level in keratinocytes.
? Research & Clinical Relevance
Dermatology:
SCEL is a biomarker of keratinocyte differentiation.
Studied in disorders of cornification, psoriasis, atopic dermatitis.
Cancer Research:
Dysregulated SCEL expression reported in some epithelial cancers (e.g., oral squamous cell carcinoma).
Developmental Biology:
Important for studying skin barrier formation and epidermal morphogenesis.
✅ In summary:
SCEL antibodies are research reagents targeting sciellin, useful in dermatology, cancer biology, and epithelial differentiation studies, typically applied in IHC, WB, and IF assays.
